15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)

Also Known As:

(15S)-Hydroxy-11 alpha, 9 alpha-(epoxymethano)prosta-5Z, 13E-dienoic Acid; (15S)hydroxy- 9alpha,11alpha- (epoxymethano)prosta- 5,13- dienoic acid; 11 alpha,9 alpha-Epoxymethano PGH2; 9,11-Dideoxy-11 alpha,9 alpha-epoxymethanoprostaglandin F2 alpha; 9,11-Dideoxy-11 alpha,9-alpha-epoxymethano-PGF2 alpha; 9,11-epoxymethano-PGH2; U-44619; U-46619; U44619; U46619; 11 alpha,9 alpha Epoxymethano PGH2; 9,11 epoxymethano PGH2; U 44619; U 46619; 5-Heptenoic Acid, 7- (6- (3- Hydroxy- 1- Ocentyl)- 2- Oxabicyclo(2.2.1)hept- 5- yl)- , (1R-(1alpha,4alpha,5 beta(Z),6alpha(1E,3S*)))-

Pharmalogical Action Categories:

Vasoconstrictor Agents

Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Oxides: 2508
        Peroxides: 1274
        Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Peroxides: 1274
      - Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
- Oxygen Compounds: 12
  - Oxides: 2508
    - Peroxides: 1274
      - Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
Organic Chemicals: 133
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Peroxides: 1274
      - Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Synthetic Prostaglandins: 823
    - Synthetic Prostaglandin Endoperoxides: 1
      - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandin Endoperoxides: 23
        Prostaglandins H
        Prostaglandin H2: 136
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: 357

Daniel Manz Selected Research

Daniel Manz Research Topics

Disease

Drug/Important Bio-Agent (IBA)